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A fundamental building block in any graph algorithm is agraph container -- a data structure used to represent the graph. Ideally, a graph container enables efficient access to the underlying graph, has low space usage, and supports updating the graph efficiently. In this paper, we conduct an extensive empirical evaluation of graph containers designed to support running algorithms on large graphs. To our knowledge, this is the firstapples-to-applescomparison of graph containers rather than overall systems, which include confounding factors such as differences in algorithm implementations and infrastructure. We measure the running time of 10 highly-optimized algorithms across over 20 different containers and 10 graphs. Somewhat surprisingly, we find that the average algorithm running time does not differ much across containers, especially those that support dynamic updates. Specifically, a simple container based on an off-the-shelf B-tree is only 1.22× slower on average than a highly optimized static one. Moreover, we observe that simplifying a graph-container Application Programming Interface (API) to only a few simple functions incurs a mere 1.16× slowdown compared to a complete API. Finally, we also measure batch-insert throughput in dynamic-graph containers for a full picture of their performance. To perform the benchmarks, we introduce BYO, a unified framework that standardizes evaluations of graph-algorithm performance across different graph containers. BYO extends the Graph Based Benchmark Suite (Dhulipala et al. 18), a state-of-the-art graph algorithm benchmark, to easily plug into different dynamic graph containers and enable fair comparisons between them on a large suite of graph algorithms. While several graph algorithm benchmarks have been developed to date, to the best of our knowledge, BYO is the first system designed to benchmark graph containers. 

Pain relief on-demand Chronic pain is a debilitating condition for which there are no effective treatments. The primary somatosensory cortex (S1) and the anterior cingulate cortex (ACC) are involved in decoding pain components, and electrical stimulation of the prefrontal cortex (PFC) has been shown to exert analgesic effects. Here, Sun et al. developed a multiregion brain-machine interface (BMI) able to detect pain from electrical signals in S1 and ACC and provide on-demand PFC stimulation. The BMI was able to accurately detect and treat acute and chronic pain in rats; the analgesic effects were stable over time. The results suggest that BMI approaches might be effective for treating chronic pain of different etiologies. 

The skip list is an elegant dictionary data structure that is com- monly deployed in RAM. A skip list with N elements supports searches, inserts, and deletes in O(logN) operations with high probability (w.h.p.) and range queries returning K elements in O(log N + K) operations w.h.p. A seemingly natural way to generalize the skip list to external memory with block size B is to “promote” with probability 1/B, rather than 1/2. However, there are practical and theoretical obsta- cles to getting the skip list to retain its efficient performance, space bounds, and high-probability guarantees. We give an external-memory skip list that achieves write- optimized bounds. That is, for 0 < ε < 1, range queries take O(logBε N + K/B) I/Os w.h.p. and insertions and deletions take O((logBε N)/B1−ε) amortized I/Os w.h.p. Our write-optimized skip list inherits the virtue of simplicity from RAM skip lists. Moreover, it matches or beats the asymptotic bounds of prior write-optimized data structures such as Bε trees or LSM trees. These data structures are deployed in high-performance databases and file systems.